It really depends on your airframe. You will still need "extra" thrust to climb, above the thrust required for cruise, but that thrust can be generated at higher airspeed rather than at the lower airspeeds for takeoff where a high pitch prop might stall. Unlike a multicopters or aerobatic planes the thrust to weight is not necessarily the right metric to design a quadplane by (or any plane) for range or endurance, as the thrust should actually overcome whatever drag, including induced drag from lift, the aircraft has at that particular airspeed.
For best range or endurance it is important to have a propulsion motor and propeller setup that produces "just" enough thrust to overcome the drag at that particular desired airspeed. A way to think of the relationship of thrust and drag is that the consequence of drag is that it reduces aircraft altitude, and that "just enough" thrust will keep the drag from making the aircraft descend. Also one can produce more thrust than is required (from say a prop that has a over diameter prop) and one can produce thrust at the wrong airspeed (from the wrong prop pitch). So whilst a prop with good low airspeed thrust is good for takeoff, it's unlikely to be ideal for the thrust required at high speed cruise. Further on launch a prop needs extra thrust to accelerate the aircraft to above stall speed and for climbout, a quadplane does not as it uses the quad motors for takeoff and can maintain enough lift for flight whilst the forward prop can slowly accelerate it to over stall speed, where the wings can take over the lift required to maintain altitude.
Typically to get the most efficient cruise you first find the aircrafts best glide slope airspeed and fly about 1.32 times faster for best range, and 1.32 times slower for best endurance. This "most efficient cruise" is also known as Carson's speed. So once you know if you want best endurance or best range, you then select a motor/prop that produces enough thrust at that aircraft airspeed. Note that with electric motors, unlike combustion engines, you can easily over dimension the electric motor to produce enough thrust for climbing, whilst still being able to throttle back for just enough for cruise, without it negatively impacting motor efficiency. That means provided you have enough motor torque and RPM you should be able to configure the prop for "just enough" thrust to overcome drag at cruise, and still have enough reserves to climb at cruise airspeed. The prop will simply be "tuned" to the best cruise airspeed, rather than the typical compromise to allow for low stall speeds.
Given that lift is also dependent on airspeed, adding weight, in the form of batteries, also means that the Carson speed increases and typically also range. Adding weight to any aircraft increases wing loading, and also stall speed. But if you have a "unlimited runway" in the form of the quadmotors, this results in better overall aircraft cruise performance as you no longer have to have wings with a low stall speed to safely takeoff and land, nor a high thrust, low airspeed forward prop that is not effective at cruise.
Hope that helps.