Need help to find out what causing the Vibration in Auto mode!

I have assembled a pixhawk 2 with KV380 motor, 16x5.4prop and when i flew it using Althold and Loiter mode there is no Vibration that appears but when i tested it on a mission the vibration comes up… i do have a good motor balanced when i test in Loiter and Althold but when in auto i have a motor imbalanced… thanks for anyone who could help i have shared the bin file of my copter.

Disable Require Access to the file for help.

sorry i forgot to remove restrictions earlier now there is no restriction for my bin file