Hi,
The closest result you can get ist to run MAVLink only.
You will still be limited by the available bandwidth of the air link.
I started using TBS Crossfire with the wish to get rid of the SIK-Radios and still have the same functionality.
If you reduce it to MAVLink1 (just 8 channels and other limitations etc.) it worked kind of but was never the same as a real SIK-radio. I was never able to load a mission or change parameters while flying in a reliable way.
With a Sik-radio loading a mission in flight is no issue.