Calibrating BLHeli-S ESCs

Does BLHeli-S work with NuttX in an original Pixhawk flight controller on a hexacopter (in this case a Hobbyking HKPilot32 clone)? That is, can I calibrate all the ESCs with BLHeli-S at the same time with the standard calibration methods we have been using for the past several years, without resorting to getting a new operating system like ChibiOS? Thank you.

Sure. Standard PWM or Onshot/Oneshot125 should work. Passthrough for BLHelisuite won’t work of course.