4in1 esc to pixhawk cube

I have a 4 in 1 esc https://store-en.tmotor.com/goods.php?id=1016 and i want to use to with pixhawk 2 cube. Is it possible?
I read the previous thread but it created some confusion.
Can someone help me with the complete step by step guide with the following:

  1. How to connect it to pixhawk.
    2.What parameters are to be changed.
  2. How to calibrate and setup the ESC.
    Thankyou in advance for the help.

A 4in1 is just 4 ESC’s on one board so of course it’s possible and very common. Nothing different is done when using them. The signal inputs are on the 10poin connector.

can you please elaborate

Not much to elaborate on. The Main outputs from the Flight Controller connect to the signal inputs on the 4in1 10 pin connector. They are labeled 1-4. The pin labeled CRT is total current output, the pin ;labeled Tx is ESC telemetry. That’s it.

Hello bro.
did you connected 4 in 1 esc to pixhawk?

This is trivial. There is no problem connecting a 4-in-1 to any flight controller.