Transmit via USB?

Is it possible to transmit telemetry packets originating from a computer over USB port? For example, lets say I had 2 assets in the air, and an antenna tracking setup that expected a telemetry connection from sik radio. I also have a ground station that has GPS data coming in over a wifi setup. Would it be possible to connect to the tracker over the radio so I could have it track different assets on demand?

Obviously if you just plug a USB cable from the PC into the ardupilot hardware (Pixhawk for instance) that will work.
Its not clear what the GPS is doing to the ground station.
Why can’t you connect to the tracker over telem Radio? What’s stopping you? Sorry if I’ve missed something simple but I really don’t understand what the issue is.

Thanks, Grant.