Pixhawk PX4 2.4.8 powering with USB and battery at same time

Hardware Pixhawk family
1

Thanks in advance for advice
New to Pixhawk PX4 2.4.8 controller do I have to worry about plugging in USB cable and Power Module and the same time?
This was never recommended with APM boards?
Thanks

2

I have do like that,it doesn’t matter.