Pixhawk 2.4.8 is not connecting to mission planner but connecting to qground control

I am using a Pixhawk 2.4.8 , I was using for last 2 months but suddenly when I try to connect it to mission planner it was detecting com3 but it was not connecting to , I am using Pixhawk 1 firmware. My Pixhawk 2.4.8 is connecting to qground control. What should I do