No connection with 433 MHz SiK radio - no Mavlink Heartbeat Packets

I check topics about this problem, but I have’nt found any solution.
My QuadRotor, Pixhawk4, Arducopter 4.3.6, USB connection 115 is ok with Mission Planner 1.3.80
But with 433 SiK radio (green leds solid), Telem1, serial1, (protocol 2 or 10 frsky) at 57200 b, no connection establishes after timeout delay.
That’s pity because with old version it was running.
I changed USB port, another PC…
Help !