MP/ APM planner Connection to Pixhawk

Hi all…
I’ve been having a real time of it. (Pixhawk and 3.2.1FW)

Having just returned from holiday and taken out my quad for a spin (previously working perfectly), I was rather irritated to find that I could not connect via the 3DR radio with my Android device, nor could I arm the Pixhawk, as there was no satelite fix (open playing field) and the OSD was receiving no telemetry at all.

Having returned home in disgust, I tried without success to connect with MP.
So I decided to reinstall the copter firmware having overwritten with plane 3.3.1.

With firmware loaded, I then tried to connect and got failure after failure, mainly due to ‘Access denied to
Com 1 port’. Despite the serial port showing in the device manager, and working.

So I tried clearing the port register using regedit, with little luck, and then tried connecting with APM planner, eventually succeeding, only by going the "wizard’ route…

This has all proved to be very tedious indeed, and I wonder why it should suddenly be so difficult to connect to the Pixhawk… Even on my laptop.
Has anybody else suffered the same frustration?

Any wisdom would be most welcome!. Best DP