Wanting to update my Copter to the latest 4.2 beta build today, I first updated MP to the latest beta, as is usually best practice. I can no longer connect to any MAVLink serial device (multiple flight controllers and radios attempted). I tried reinstalling drivers, but it’s not a driver problem. MAVProxy connects fine.
Reverting to 1.3.76 stable from the GitHub releases page (1.3.8029.15962) allows for successful connection.
EDIT: I forgot that you have to do a manual update from the current stable release because of the AppVeyor oddities. A manual update to the beta release results in the same, broken behavior.
regarding this error, this one is a odd one, but the manualy fix it
open
MissionPlanner.exe.config
in a text editor
seach for system.io.compression
and rename it to something invalid
eg system.io.compression1234