Large Quadcopter tips

I am about to finish setting up a Foxtech devourer quadcopter running 30" props using a pixhawk.

I was wondering if anyone had tips for tuning and setting up such a large quadcopter.

Will autotune work reliability with this quad?

Is the stock 3M vibration foam pads adequate for vibration dampening?

are the default PID’s ok for an initial flight with this large of a quad?

Thank you