Could the new Pi Zero 2 handle Ardupilot plus taking full res 12MP photos?

There’s this shield for the Pi Zero, which is under active development: OBAL - A Simple Linux-based Raspberry-Pi Ardupilot FCB - #11 by brunoolivieri

Otherwise, plenty of people use separate flight controllers. Something like a Kakute or small Matek board can interface with the Pi Zero quite easily. Not sure if it’ll exceed your weight budget though.