APD 12S ESC Compatibility with Pixhawk

We’re trying to build a Multirotor with the Pixhawk. Does APD’s 12S 120A ESC work well with the Pixhawk? Currently planning a quad, may choose to upgrade it to a coaxial octo in the future.

Link to the ESC in question: Team BlackSheep Online Store - Advanced Power Drives APD 120F3[X] 12S 50V 120A

Yes
You can use DSHOT if you have suitable outputs, and telemetry input to serial port.

Or PWM if you have to.