I have cube orange and I want to setup a copter which has 12 motors.
I use this page for motors settings: http://www.iforce2d.net/mixercalc/
As you can see in the image below, The frame that I chose for my multirotor is a little different:
yes, it can do that, but you do need to adapt the motor mixer values a bit. there is an example on how to do it using lua scripting.
With that method you do not need to change the firmware, just upload a simple small script.
If you use FETtec OneWire ESCs you will also be able to get telemetry from all 12 motors using a single wire.