Autonomous flying with Pixhawk 6x has uneven motor speeds

ArduCopter Copter 4.5
2

Here are some suggestions:

  1. Do not disable ANY failsafes, they are there for a reason.
  2. Check that you are not using hardware that should be avoided
  3. Make sure to follow these hardware best practices
  4. Enable RC, mount the GPS and configure the vehicle correctly
  5. Tune the PIDs
  6. Once that is done and the drone operates reliably, remove the RC and the GPS and try again.

I edited the title of your post to better reflect the content

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