IMU Offset reaction

Due to design choices, my cube is not going to be a the center of gravity. I read the article in the wiki about using the Offsets parameters, but there is something worrying me. It says depending on the position, like on the nose of the drone, if it leans back and the nose goes up, this vertical acceleration could lead to a decrease in the throttle.

My question, for those with the experience with imu’s offset, how much this affect the control of the drone?