Copter with two different motors and two different props

Hi,

A possibly stupid question here.

How difficult it would be to set up and tune a copter where there would be two types of motors and two types of props, and with the arm length being different. I am thinking of something like:
two higher power motors with 5 x 8 props.
two lower power motors (something like Xing 2306 1800 kV) with 5 x 3 props.

(the idea is to make a high speed medium endurance VTOL, with two foldable arms).

ArduCopter will handle this pretty well w/ stock firmware and a good tune. A custom motor mixer might help.

I saw a PR mentioned in the most recent dev call that suggested that one limiting factor is the mot parameters being applied in a blanket fashion to heterogeneous motors.